Products & Services

PNS Services

Partner with scientific experts to evaluate peripheral nerve safety and neuroprotective efficacy across therapeutic modalities, including small molecules and antibody-drug conjugates. Our services span established PNS assay workflows, custom study designs, and custom model development to generate decision-ready data for preclinical drug development.

Services for PNS Toxicity and Neuroprotection

PNS Services provide human-relevant insights into peripheral nerve safety and neuroprotective drug efficacy using sensory neuron-Schwann cell models. Studies can be tailored to your program stage, research question, and decision criteria—from early safety profiling to neuroprotection efficacy testing and custom peripheral nerve workflows.

PNS Services Advantages

Human PNS Biology

Assess drug effects in human peripheral nerve models with iPSC-derived sensory neurons and primary Schwann cells.

Structural + Functional Endpoints

Measure both nerve morphology and conduction for comprehensive insights.

Flexible Study Scale

Move from scalable compound screening to deeper functional characterization with complementary PNS-2D and PNS-3D workflows.

Efficient Turnaround

Receive study reports in as little as 2 weeks for PNS-2D or 9 weeks for PNS-3D.

Offerings

Peripheral Nervous System Models

PNS Services include complementary 2D and 3D human peripheral nerve models designed to support different stages of preclinical testing. PNS-2D enables scalable morphology-based screening, while PNS-3D adds longitudinal electrophysiology for deeper characterization of nerve function.

PNS-2D

PNS-2D incorporates human sensory neurons and Schwann cells in a 96-well format to assess drug-induced changes in cell health, neurite networks, and Schwann cell morphology. This workflow supports rapid drug candidate screening and rank ordering.

PNS-3D

PNS-3D incorporates human sensory neurons and Schwann cells in a 3D microenvironment with embedded electrode arrays, forming 10 mm-long myelinated nerve fibers. Longitudinal electrophysiology and morphology endpoints support characterization of peripheral nerve dysfunction and neuroprotective effects over time.

Service

PNS Toxicity

Predict peripheral neuropathy risk by measuring drug-induced changes in human peripheral nerve conduction and structure.

PNS-2D and PNS-3D help identify peripheral neuropathy risk before clinical testing using human sensory neurons and Schwann cells. PNS-2D enables morphology-based screening across large compound sets, while PNS-3D integrates electrophysiology and morphology for more sensitive characterization of peripheral nerve dysfunction.

Learn More

Representative PNS-2D images showing toxicity-associated neurite loss and Schwann cell retraction, supporting morphology-based screening for peripheral neuropathy risk.

Service

Neuroprotection

Rank neuroprotective candidates by their ability to prevent chemotherapy-induced neuropathy.

PNS-2D and PNS-3D enable rank ordering of neuroprotective candidates by measuring protection against chemotherapy-induced nerve dysfunction. Electrophysiological and morphological endpoints reveal whether drug candidates preserve peripheral nerve function and structure, helping prioritize therapies with the strongest protective effect.

PNS-3D electrophysiology metrics show differential neuroprotective effects over time, with NB-7 and WX-02-37 preserving function longer than DSRM-3716 following vincristine-induced injury.

Service

Custom Services

Custom PNS studies tailored to your research objectives.

Custom Services offer tailored endpoint panels, modified study designs, and custom disease model development. For genetic disease modeling, organoid models are generated from cell lines provided by your team or CRISPR-engineered mutations, enabling human-relevant assessment of disease biology and therapeutic response.