Products & Services

CNS-3D Induced Alzheimer's Model

Evaluate anti-amyloid beta drug efficacy using an assay-ready kit containing human neuroimmune organoids and exogenous amyloid beta. Designed to support human-relevant assessment of amyloid-driven phenotypes, inflammatory responses, and therapeutic effects.

Evaluate Anti-Amyloid Beta Drug Efficacy

Designed for anti-amyloid beta efficacy studies, the CNS-3D Induced Alzheimer’s Model helps researchers assess whether drug candidates reduce amyloid-driven cellular, inflammatory, molecular, and functional changes. By standardizing disease induction, it reduces the burden of model development so teams can focus on evaluating candidate efficacy. For teams that want full study execution and analysis, the same workflow is also available through CNS Services.

Key Advantages

Standardized
AD  Workflow

Combines assay-ready organoids, amyloid beta oligomers, and a defined protocol to reduce workflow setup and support reproducible disease induction.

Human Neuroimmune Context

Evaluate amyloid-driven effects in a 3D brain model containing neurons, astrocytes, and microglia.

Flexible Study
Execution

Run studies in-house or partner with CNS Services for customized study design, execution, and analysis.

Application

Alzheimer’s Disease

Assess Alzheimer’s drug efficacy in a human model of amyloid-driven pathology.

Induce Alzheimer’s-relevant phenotypes—including tau phosphorylation, apoptosis, neuronal network disruption, and gene expression changes—through exogenous amyloid beta exposure in the CNS-3D Induced Alzheimer’s Model. This assay enables higher-throughput evaluation of whether drug candidates reduce amyloid-driven pathology and preserve neuronal function.

Learn More

Amyloid beta oligomers induce concentration-dependent suppression of neuronal network activity, measured by calcium imaging.

Offerings

Products & Services

Access the CNS-3D Induced Alzheimer’s model as an assay-ready solution for in-house studies or through CNS Services for end-to-end study design, execution, and analysis.