Products & Services

CNS-3D Inflammatory Organoids

The only assay-ready immunocompetent brain organoid model for studies of neuroinflammatory mechanisms and drug efficacy. Model inflammation-driven changes in human neural tissue to investigate neuroimmune mechanisms and evaluate drug efficacy in a cortical brain model containing neurons, astrocytes, and microglia.

Model Neuroimmune Biology in Human Brain Organoids

CNS-3D Inflammatory Organoids are human iPSC-derived cortical organoids containing neurons, astrocytes, and microglia for studies of neuroinflammation, Alzheimer’s disease, and drug efficacy. This immunocompetent 3D brain model enables assessment of inflammation-driven changes in neural function, microglial activation, cytokine release, and tissue-level responses in a human cellular context.

Functional calcium imaging can be combined with complementary endpoints spanning imaging, cytokine analysis, and molecular profiling to support comprehensive insights into neuroinflammatory biology. CNS-3D Inflammatory Organoids are available as assay-ready products for in-house workflows or through CNS Services for end-to-end study design, execution, and analysis.

Key Advantages

Immunocompetent
3D Brain Model

The only commercially available 3D brain model incorporating microglia for neuroinflammation studies.

Flexible
Study Scale

Run studies in 24-, 48-, 96-, or  384-replicate formats.

Reproducible Performance

Standardized production and QC support consistent performance across studies.

Application

Neuroinflammation

Evaluate anti-inflammatory drug efficacy in a human neuroimmune model.

Recapitulate hallmarks of neuroinflammation—including microglial activation, pro-inflammatory cytokine release, and disruption of neuronal network activity—and evaluate anti-inflammatory therapeutics with CNS-3D Inflammatory Organoids. Integrated functional and inflammatory endpoints help quantify drug candidate efficacy and support human-relevant prioritization of therapies that suppress inflammation and preserve neural function.

Learn More

LPS stimulation increases microglial and astrocyte signal in CNS-3D Inflammatory Organoids, as shown by IBA1 and GFAP staining under control and inflammatory conditions.

Offerings

Products & Services

Access CNS-3D Inflammatory Organoids as assay-ready products for in-house studies or through CNS Services for end-to-end study design, execution, and analysis.