Products & Services

CNS-3D Myelinated Organoids

The only assay-ready myelinated brain organoid model to quantify myelin loss, natural recovery, and dose-dependent remyelination. CNS-3D Myelinated Organoids contain neurons, astrocytes, and oligodendrocyte lineage cells, enabling human-relevant assessment of myelin biology, neural function, and therapeutic repair.

Quantify Myelin Biology in Human Cortical Organoids

CNS-3D Myelinated Organoids are human iPSC-derived cortical organoids containing neurons, astrocytes, and oligodendrocyte lineage cells, enabling researchers to study myelin biology in a structured 3D human model. This cellular composition supports formation of myelinated axons and enables measurement of myelin dynamics alongside functional, structural, and molecular endpoints.

By capturing myelin loss, natural recovery, and therapeutic repair within the same biological context, CNS-3D Myelinated Organoids provide a human-relevant model for evaluating demyelination risk and remyelinating therapeutic efficacy. CNS-3D Myelinated Organoids are available as assay-ready products for in-house workflows or through CNS Services for end-to-end study design, execution, and analysis.

Key Advantages

Human
Myelin Biology

The only commercially available 3D brain model incorporating oligodendrocytes for studies of human myelin biology.

Quantifiable Remyelination

Assess remyelinating drug efficacy using structural and molecular endpoints.

Screening-Ready
Scale

Run myelination studies in standardized 96- and 384-replicate formats designed for scalable testing.

Application

Myelination

Evaluate remyelinating drug efficacy by quantifying myelin loss, recovery, and repair.

CNS-3D Myelinated Organoids enable the quantification of myelin loss, natural recovery, and drug-induced remyelination in a human context that better reflects the slower, often incomplete myelin loss and repair dynamics seen in human disease. Integrated structural, functional, and molecular endpoints reveal whether drug candidates restore myelin integrity and improve neural function.

Representative image of CNS-3D Myelinated Organoid at 12 weeks, showing neurons (NFH, magenta) and myelinating oligodendrocytes (MBP, green).

Offerings

Products & Services

Access CNS-3D Myelinated Organoids as assay-ready products for in-house studies or through CNS Services for end-to-end study design, execution, and analysis.