28bio CNS-3D Brain Organoids are human iPSC-derived cortical organoids composed of neurons and astrocytes that self-organize into functional networks exhibiting spontaneous calcium oscillations. The model supports spontaneous calcium oscillations and expresses key lineage markers, enabling assessment of both structural and functional drug response.

This note summarizes key findings from a peer-reviewed study which evaluated the performance of CNS-3D for detecting clinical neurotoxicity and highlights how the technology can support early neurotoxicity risk assessment in drug discovery.

Physiologically Relevant and Functional
Human iPSC derived CNS-3D Brain Organoids exhibit spontaneous calcium oscillations, enabling direct assessment of neuronal function.

Low False Positive Neurotoxicity
CNS-3D exhibits 53% sensitivity and 93% specificity, identifying clinically relevant risks while keeping safe drugs in play.

Actionable Early-Stage Screening
‍CNS-3D supports earlier, higher confidence neurotoxicity hazard identification than conventional nonclinical models.

‍